Role of AMPK signaling in Repigmentation- An Insilico study

Thenmozhi M; Murugesan A; Kumaravel S.T

doi:10.34256/irjmtcon34

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DOI: 10.34256/irjmtcon34

Role of AMPK signaling in Repigmentation- An Insilico study

Thenmozhi M⁺⁻
Murugesan A⁺⁻
Kumaravel S.T⁺⁻

Assistant Professor, Department of Biotechnology, Selvam College of Technology, Tamil Nadu, India.

Professor, Department of Mechanical Engineering, KSRangasamy College of Technology, Tamil Nadu, India.

Assistant Professor, Department of Mechanical Engineering, Paavai College of Engineering, TamilNadu, India.

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Abstract

Vitiligo is an epidermal disorder causes depigmented patches resulted from the loss of melanocytes, Autoimmunity hypotheses strongly supports that the immune system compartments responsible in the development of vitiligo. Adenosine MonoPhosphate kinase (AMPK) signaling plays a role in regimentation in vitiligo. In this present study, set of ligands selected to dock against AMPK protein in the AMP binding site using FlexX software. Based on the scores and protein-ligand interactions selected ligands were analyzed for its binding affinity and protein ligand stability for its further drug development process.

Keywords

Vitiligo, autoimmunity, AMP, AMPK,

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