Abstract

Biomaterials have become a key element in revolutionizing regenerative medicine, providing novel approaches to address a wide range of medical issues. Recent developments in biomaterials are tailored for conditions like osteoarthritis (OA), chronic wounds, erectile dysfunction (ED), and post-surgical tumor management. Composite hydrogels, such as GelMA/dECM, have shown promise in reducing chondrocyte pyroptosis and promoting osteochondral repair by recruiting mesenchymal stem cells. Additionally, the creation of MnO2 at CeOx-GAMP as a radiosensitizer demonstrates the potential of nanomaterials to activate the STING pathway, enhancing the effectiveness of radiotherapy. Functional hydrogels are being studied for skin wound healing applications, utilizing electric field stimulation and real-time healing monitoring through impedance mapping. Enzyme engineering, such as ChASE37, has proven effective in breaking down inhibitory proteoglycans in the central nervous system, aiding neuronal regeneration. The use of NIR-responsive hydrogels loaded with polydeoxyribonucleotides highlights innovative techniques for treating chronic wounds by enabling targeted drug delivery and promoting angiogenesis. For nerve injuries, magnetic mesoporous silica nanoparticles loaded with neurotrophic peptides have shown potential in restoring erectile function. Lastly, biomimetic nanofiber patches inspired by butterfly wings combine the advantages of tumor cell destruction and wound healing. These advancements exemplify the diverse applications of biomaterials, emphasizing their role in improving therapeutic efficacy and patient outcomes. As the field progresses, biomaterials hold the potential to dramatically transform healthcare and elevate the quality of life for millions worldwide.

Keywords

Biogenerate, Regenerative medicine, Osteoarthritis, Chronic Wounds, Nanomaterials, Tissue Regeneration,

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References

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